Causes of Tire Vibration Tire vibration while driving is a clear sign that something is wrong with your wheels or suspension system. Here are the top causes: 1. Wheel Imbalance The most common cause, especially Can Over Inflated Tires Cause Vibration 'What the [Expletive] Is That?:' Customer Complains Car is 'Shaking Like Crazy.' Then His Mechanic Takes a Closer Look At The Tire Wheel Shake Solved Vibration Gone For Free Out of Balance Tires: Causes and Solutions, by UTires Expert